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What are the long term effects of taking gabapentin? Long-term effects. According to the authors of a 2010 study paper, people with preexisting kidney disease may experience potentially fatal toxicity when taking gabapentin. Gabapentin may cause other long-term effects, including memory loss, weakened muscles, and respiratory failure. How long does Tegretol stay in your system? Approximately 93.5 hours (4 days). It takes 5.5 x elimination half-lifes for a medicine to be cleared from ones system. The elimination half-life of Tegretol varies depending on whether it is initial dose or repeated dosing. Initial half-life values range from 25-65 hours, decreasing to 12-17 hours on repeated doses.
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